Buy Haemo sorbents the carbon raised SKN durabilities
Haemo sorbents the carbon raised SKN durabilities

Haemo sorbents the carbon raised SKN durabilities

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Technical characteristics
  • BrandФеникс-АМП
  • Country of manufactureUkraine
Description

Haemo sorbents the carbon raised SKN durabilities in the columns of sorption disposable (CSD) are intended for purification of blood out of an organism and are recommended at a sharp and chronic renal failure, a hepatic coma and a prekoma, biliarny cirrhosis, at the subcompensated portal cirrhosis, by preparation and after liver operation and zhelchevyvodyashchy channels, at sharp poisonings with the barbiturates chlorinated by hydrocarbons, fosfororganichesky insecticides, salycylates, tritsiklichesky antidepressants, alkilirmiruyushchy preparations and anti - metabolites, alkaloids, mushroom toxins, etc.

Besides haemo sorbents of SKN are effective in therapy of a number of the toxicoses caused by extensive inflammations and disintegration of fabrics, for example, at peritonitis, pancreatitis, sepsis, a burn disease, position ischemia and also at treatment of some skin and mental diseases.

Currently the last development is SKN - 2K haemo sorbent.

The quality certificate of a haemo sorbent of SKN - 2K in columns of sorption disposable KSO

Physical and chemical characteristics:

Parameters On TU U 88 258.019 - 98 Actually
Maintenance of working fraction, % Not less than 90,0
The volume of a time on benzene, cm3/g Not less than 1,0
Bulk weight, g/cm3 No more than 0,5

Absorbing properties:

Marker On TU U 88 258.019 - 98 Actually
Bilirubin, mg/g Not less than 0,6
Phenol, mg/g Not less than 15,0
Creatine, mg/g Not less than 50,0
Uric acid, mg/g Not less than 80,0

Medicobiological characteristics:

Parameters On TU U 88 258.019 - 98 Actually
Sterility Sterile Sterile
Pirogennost Apirogenny Apirogenny
Toxicity Nontoxical Nontoxical
Dust content, % No more than 5
Decrease in number of platelets, % No more than 10
Decrease in number of leukocytes, % No more than 15
Gain of free hemoglobin, % mg No more than 10
Tightness Tight Tight

SKN - 2K haemo sorbent in columns of disposable KSO conforms to requirements of TU U 88 258.019 - 2000.

Instruction for application of a haemo sorbent of SKN - 1K

1. General provisions.

SKN - 1K, SKN - 2K represents the granulated high - porous absorbent carbon like SKN or GSGD from the high - polymeric DNA imparted on its surface (not less than 0,5 mg of DNA on 1 ml of coal). SKN - 1K, SKN - 2K selectively deletes from blood, plasma and other DNA - connecting biological liquids of substance, keeping at the same time the high nonspecific absorbing capacity inherent in synthetic carbon haemo sorbents.

2. Main characteristics of SKN - 1K, SKN - 2K (TU 88 USSR 107.002 - 91)

2.1. SKN - 1K, SKN - 2K represents the granules of black color which are in transparent or opalestsiruyushchy liquid (ethyl alcohol).

2.2. Quantity of the immobilized DNA not less than 0,5 mg on 1 ml of coal.

2.3. It is sterile, apirogenen, is nontoxical.

2.4. Is issued in disposable polymeric columns with a capacity of 50, 100 and 200 ml.

3. Method of application

Massoobmenniki with CKH - 1K, CKH - 2K do not need additional sterilization. Before haemo - or a plazmosorbtion for removal of 96% of ethyl alcohol a massoobmennik wash out sterile apirogenny 0,9% NaCl solution on a vytok according to table 1.

Table 1

Volume of a column, ml Volume of washing, l Speed of washing, ml/min.
50 1,0 50
100 1,5 100
200 2,0 150

After a sorbent otmyvka from ethyl alcohol for the purpose of dust removal of a sorbent 150 ml of the physical solution containing 10 000 honey of heparin within 10 minutes according to tab. 1 make its recirculation otmyvka.

The recommended haemo perfusion speed for a massoobmennik of 50 ml - 15 - 25 ml/min. , 100 ml - 30 - 40 ml/min. , 200 ml - 50 - 90 ml/min. The average level of an initial geparinization - 300 me/kg the patient's weight. When studying efficiency of CKH - 1K, CKH - 2K concerning each separate nosological unit it is desirable to begin with one session haemo - or plazmosorbtion on a column with a capacity of 100 ml with the subsequent clinical laboratory control of a condition of the patient within 2 - 3 weeks. Further varies the frequency of carrying out extracorporal procedures, volume and number of columns, volume of perfusions depending on character and disease severity taking into account the received results.

4. Indications to application

SKN - 1K, SKN - 2K is intended for treatment of a system red volchanka, rheumatoid arthritis, psoriasis (especially psoriatichesky artropatiya), chronic active hepatitis, a poliradikulonevrit, a post - radiation neurosomatic polipatiya, bronchial asthma, medicinal and food allergy, etc. immunodependent diseases.

5. Contraindications to application

Existence of potential sources of bleeding. Falling of arterial pressure is lower than 90/50.

6. Storage conditions

Massoobmennnki with CKH - 1K, CKH - 2K has to be stored at the room temperature in the dry and pure rooms ensuring safety of packing.

The instruction for application of haemo sorbents carbon the increased durability SKN - 1K SKN - 2K

in columns of sorption disposable KSO

1. Appointment

Haemo sorbents the carbon raised SKN durabilities in the columns of sorption disposable (CSD) are intended for purification of blood out of an organism and are recommended at a sharp and chronic renal failure, a hepatic coma and a prekoma, biliarny cirrhosis, at the subcompensated portal cirrhosis, by preparation and after liver operation and zhelchevyvodyashchnkh channels, at sharp poisonings with the barbiturates chlorinated by hydrocarbons, fosfororganichesky insecticides, salycylates, tritsiklichesky antidepressants, alkiliruyushchy preparations and antnmetabolita, alkaloids, mushroom toxins, etc. Besides, haemo sorbents of SKN are effective in therapy of a number of the toxicoses caused by extensive inflammations and disintegration of fabrics, for example, at peritonitis, pancreatitis, sepsis, a burn disease, position ischemia and also at treatment of some skin and mental diseases.

2. Characteristics

2.1. Haemo sorbents carbon the increased durability of SKN are issued packaged in the column sorption disposable (CSD) with a capacity of 50, 100, 200, 300 ml and, depending on the volume of a sorption time on benzene, have the brands specified in table 2.

Table 2

Brand of haemo sorbents The volume of a sorption time on benzene, cm3/g
CKH - 1K - 50
CKH - 1K - 100
SKN - 1K - 200
SKN - 1K - 300
SKN - 2K - 50
CKH - 2K - 100
SKN - 2K - 200
CKH - 2K - 300
not less than 0,9
not less than 0,9
not less than 0,9
not less than 0,9
not less than 1,0
not less than 1,0
not less than 1,0
not less than 1,0

2.2. Maintenance of working fraction not less than 90% of lump.

2.3. Bulk weight is 1 cubic cm of SKN - 1K no more than 0,42 g, SKN - 2K - no more 0,38g.

2.4. Dust content no more than 5% .

2.5. Capacity on bilirubin at adsorption from albumine - the containing solution not less 0,6mg/g.

2.6. Capacity on phenol at adsorption from albumine - the containing solution not less than 15 mg/g.

2.7. Capacity on creatinine at adsorption from albumine - the containing solution not less than 50 mg/g.

2.8. Capacity on uric acid at adsorption from albumine - the containing solution not less than 80 mg/g.

2.9. Decrease in number of platelets and leukocytes owing to their landing to SKN at initial contact of blood with sorbent granules no more, on platelets of - 10% ;

on leukocytes of - 15% .

2.10. Gain of free hemoglobin no more than 10 mg of % .

2.11. Haemo sorbents the carbon raised SKN durabilities in the columns of sorption disposable (CSD) are sterile, apirogenna, are nontoxical.

2.12. An identification number at the order of haemo sorbents carbon the raised SKN durabilities in the columns of sorption disposable (CSD) with a volume of a sorption time on benzene not less than 0,9 cm3/? , of 100 ml - "Gemosorbent SKN - 1K - 100 TU U 88 25 8.019 - 98". 3.

3. Application order

3.1. To check integrity of packing and an expiration date of a haemo sorbent of SKN in KSO specified on packing. Not to apply at violation of integrity of packing and excess of term of guarantee storage.

3.2. Using aseptic equipment, to cut the sterile tool external and internal packages. To establish KSO with SKN in the perfuzionny contour collected on the device for haemo sorption. For removal of the KSO ethyl alcohol with SKN to wash out sterile, apirogenny 0,9% NaCl solution on a vytok according to table 3.

Table 3

Volume of SKN, ml Volume of washing, l Speed of washing, ml/min.
50
100
200
300
0,8
1,5
2,0
3,0
75
100
150
200

3.3. In KSO to make their recirculation otmyvka for dust removal of haemo sorbents of SKN:

for KSO of 50 and 100 ml in number of 75 ml of physiological solution (0,9% of NaCi) containing 5000 ME heparins for KSO of 200 and 300 ml - 150 ml of physiological solution (0,9% of NaCi) containing 5000 ME heparins: the otmyvka is made within 10 minutes with a speed according to table 3.

3.4. The recommended speeds of perfusion of blood and its components are specified in table 4.

Table 4

Volume of SKN, ml Speed of perfusion, ml/min.
50

100

200

300

15 - 50
30 - 80

50 - 180
80 - 240

3.5. At treatment of sharp poisonings, and also for patients with a sharp and chronic renal failure the speed specified in tab. 3 doubles.

3.6. The average level of an initial geparinization - 300 ME on 1 kg of weight of the patient.

3.7. At treatment of severe forms of endogenous intoxication holding 2 - 3 sessions of haemo sorption with use of haemo sorbents of SKN is recommended.

4. Proltivopokazaniya

4.1. Contraindications to application of haemo sorbents of SKN in KSO generally coincide with contraindications to application high (250 - 500 pieces/kg) heparin doses at the expressed risk of uncontrollable bleedings.

4.2. Frustration of haemo dynamics with the maximum arterial pressure below 80 - 90 and higher than 180 mm hg, and also the expressed hypoxia caused by reduction of a respiratory surface of lungs at drain pneumonia, lung hypostasis, a shock lung, etc. belong to relative contraindications.

5. Conditions of transportation, storage and operation

5.1. To make transportation of SKN to KSO all types of the closed vehicles according to the rules of transportation existing on this type of transport at a temperature from - 20 to + 50 °C.

5.2. To store SKN in KSO in the dry enclosed space at a temperature from 5 to 40 °C.

5.3. SKN reuse in KSO is forbidden.

REFERENCE
about results of application of haemo sorbents of CKH 1K, SKN - 2 and SKN - 2K in modification an artificial liver (further SKN - 2k (0,18 - 0,22 g/cm3) in treatment of especially severe forms of poisonings with a pale toadstool at children

For the period 2000 - 20021gg. , in the conditions of the CSTO of Donetsk was on treatment of 48 children with poisoning with a pale toadstool. At all patients the phenomena of a gastroenterokolit and a toxic gepatopatiya were noted; encephalopathy, toxicosis, increase in a liver, activity increase transaminaz, high level of bilirubin, decrease in a protrombinovy index, koagulopatiya. When carrying out complex treatment, including a hemodialysis the forecast adverse. Considering inefficiency of routine, conservative therapy by all patient operations of extracorporal haemo correction were carried out by a haemo sorption method. At 29 children high - line krupnoobjemny sorption with use of haemo sorbents of CKH 1K and SKN - 2K was carried out. Speed of a stream of blood of 50 - 120 ml/min. One patient has a volume 8 - 10 OTsK, the Average number of haemo sorption 2,8. In this group 17 patients died, the lethality made 58,6% , Similar results forced to look for new ways of increase of efficiency of extracorporal haemo correction. Application of a haemo sorbent SKN - 2k (0,18 - 0,22 g/cm3) became alternative. Haemo sorption was carried out at 19 patients, 2 patients died, the lethality made 10,5% . Haemo sorption was carried out with a speed of a stream of blood of 20 ml/min. In volume of 3 - 6 OTsK. The average number of sorption at one patient was made by 1,3. SKN - 2k (0,18 - 0,22 g/cm3) led application of a haemo sorbent to fast knocking over of pathological syndromes first of all of toxicosis and encephalopathy. Normalization of biochemical indicators happened within 3 - 4 days after haemo sorption. In most cases there was enough carrying out one haemo sorption. It should be noted that disposable sterile columns are compatible to different types of highways of blood for a hemodialysis that considerably reduces time of preparation for operation that is especially important at mass arrival of patients. I consider that today, extracorporal haemo correction by a haemo sorption method with use of a haemo sorbent SKN - 2k (0,18 - 0,22 g/cm3) is a choice method in treatment of severe forms of poisonings with a pale toadstool at children. In comparison with the applied plasma exchange haemo sorption has a number of essential advantages: high efficiency, decrease in a total cost of treatment, a possibility of application at mass receipts of patients, absence of risk of infection of HVB, HVC and HIV infection.

Characteristics of haemo sorbents of SKN

1. Haemo sorbents carbon the increased durability of SKN are issued packaged in the column sorption disposable (CSD) with a capacity of 50, 100, 200, 300 ml and, depending on the volume of a sorption time on benzene, have the brands specified in table 5.

Table 5

Brand of haemo sorbents The volume of a sorption time on benzene, cm3/g
SKN - 1K - 100 not less than 0,9
SKN - 1K - 200 not less than 0,9
SKN - 1K - 300 not less than 0,9

1. Maintenance of working fraction not less than 90% of lump.

2. Bulk weight is 1 cubic cm of SKN - 1K no more than 0,42 g, SKN - 2K - no more than 0,38 g.

3. Dust content no more than 5% .

4. Capacity on bilirubin at adsorption from albumine - the containing solution not less than 0,6 mg/g.

5. Capacity on phenol at adsorption from albumine - the containing solution not less than 15 mg/g.

6. Capacity on creatinine at adsorption from albumine - the containing solution not less than 50 mg/g.

7. Capacity on uric acid at adsorption from albumine - the containing solution not less than 80 mg/g.

8. Decrease in number of platelets and leukocytes owing to their landing to SKN at initial contact of blood with sorbent granules no more,

on platelets - 10% ;

on leukocytes - 15% .

1. Gain of free hemoglobin no more than 10 mg of % .

2. Haemo sorbents the carbon raised SKN durabilities in the columns of sorption disposable (CSD) are sterile, apirogenna, are nontoxical.

Identification number at the order of haemo sorbents carbon the raised SKN durabilities in the columns of sorption disposable (CSD) with a volume of a sorption time on benzene not less than 0,9 cm3/g, of 100 ml - Gemosorbent of SKN - 1K - 100 TU U 88 258.019 - 98.
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Haemo sorbents the carbon raised SKN durabilities
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